Trigeminal Foundation

Nerve Injuries

Helping to prevent, educate and manage

Research Introduction

Aims and objectives

These are highlights of ongoing and planned research involving our team related to trigeminal nerve pain.

Short term Goals

  • Development of trigeminal pain clinical / psychological research teams for chronic orofacial pain
  • Development of expertise for chronic orofacial pain
  • Identification of research area needs using Cochrane reviews

Medium term goals

  • Evaluation of ongoing service developments for chronic orofacial pain
  • Build on existing links with IoP, Neurology, Neurosurgery, Physiotherapy
  • Development of further links with Industry to support research funding
  • Evaluation of psychological needs of OFP patients and identify best practise in management

Long term goals

  • Establishing the research team as national and international lead in trigeminal pain Establishing the research team as national and international lead in the prevention and management of trigeminal nerve injuries
  • Leading centre in pharma trials for analgesics and anxiolytics

Acute post surgical pain model (basis of clinical analgesic trials)

  • Influence of genetics, psychometrics on pain
  • Pain pathways fMRI
  • Biomarker of ongoing pain in man (proof of concept studies to follow with Perfalgen and Diclofenac)
  • Evaluation of the placebo effect
  • Immunohistochemical analysis peripheral pain receptors 

Dental pulpal pain (unravelling the modality of dental pain and Dental Sensitivity) 

  • Influence of genetics, psychometrics
  • Pain pathways fMRI insert video of MRI imaging in pain research
  • Immunohistochemical analysis peripheral receptors /effects of blocking agents
  • Evaluation of neurophysical and biological pathways
  • Cell culture of neural stem cells form dental pulp
  • Characterisation of neural cell physiology derived form human pulp
  • Evaluate novel methods of obliteration/obstruction of dentinal tubules

Chronic orofacial pain 

  • Conditions include headaches [migraine, tension, cluster, trigeminal autonomic syndromes, giant cell arteritis] neuralgias [trigeminal neuralgia –typical and atypical, post surgical neuropathy, PHN] and neuropathic pain [persistent idiopathic intra oral and extra oral pain, trigeminal neuropathy, Temporomandibular pain, burning mouth syndrome].
  • Phenotyping of patients attending OFP /neurology clinics 
  • (pain history / QST / LA blocks / Specific adjuvants)
  • Influence of genetics, psychometrics –pain questionnaires
  • Pain pathways fMRI
  • Immunohistochemical analysis peripheral receptors /effects of blocking agents
  • Evaluation of neurophysical and biological pathways
  • Evaluation of psychological needs of OFP patients and identify best practise in management

Relationship of Parkinson’s and orofacial pain

  • Epidemiology

 Trigeminal nerve injuries

  • Prevention and management optimization
  • Psychological effects of iatrogenesis

Increasing patients awareness

  • Media activity in the BBC and Tribune
  • LA related nerve injuries
  • BDJ publication (second under way).
  • The dentist article (link?)
  • National survey of dentists’ experience of these nerve injuries.
  • Prospective study evaluating novel LA practise to minimise these injuries