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Research Introduction

Aims and objectives

These are highlights of ongoing and planned research involving our team related to trigeminal nerve pain.

Short term Goals

  • Development of trigeminal pain clinical / psychological research teams for chronic orofacial pain
  • Development of expertise for chronic orofacial pain
  • Identification of research area needs using Cochrane reviews

 

Medium term goals

  • Evaluation of ongoing service developments for chronic orofacial pain
  • Build on existing links with IoP, Neurology, Neurosurgery, Physiotherapy
  • Development of further links with Industry to support research funding
  • Evaluation of psychological needs of OFP patients and identify best practise in management

 

Long term goals

  • Establishing the research team as national and international lead in trigeminal pain Establishing the research team as national and international lead in the prevention and management of trigeminal nerve injuries
  • Leading centre in pharma trials for analgesics and anxiolytics

 

Acute post surgical pain model (basis of clinical analgesic trials)

  • Influence of genetics, psychometrics on pain
  • Pain pathways fMRI
  • Biomarker of ongoing pain in man (proof of concept studies to follow with Perfalgen and Diclofenac)
  • Evaluation of the placebo effect
  • Immunohistochemical analysis peripheral pain receptors
  

Dental pulpal pain (unravelling the modality of dental pain and Dental Sensitivity) 

  • Influence of genetics, psychometrics
  • Pain pathways fMRI insert video of MRI imaging in pain research
  • Immunohistochemical analysis peripheral receptors /effects of blocking agents
  • Evaluation of neurophysical and biological pathways
  • Cell culture of neural stem cells form dental pulp
  • Characterisation of neural cell physiology derived form human pulp
  • Evaluate novel methods of obliteration/obstruction of dentinal tubules
 

Chronic orofacial pain 

  • Conditions include headaches [migraine, tension, cluster, trigeminal autonomic syndromes, giant cell arteritis] neuralgias [trigeminal neuralgia –typical and atypical, post surgical neuropathy, PHN] and neuropathic pain [persistent idiopathic intra oral and extra oral pain, trigeminal neuropathy, Temporomandibular pain, burning mouth syndrome].
  • Phenotyping of patients attending OFP /neurology clinics 
  • (pain history / QST / LA blocks / Specific adjuvants)
  • Influence of genetics, psychometrics –pain questionnaires
  • Pain pathways fMRI
  • Immunohistochemical analysis peripheral receptors /effects of blocking agents
  • Evaluation of neurophysical and biological pathways
  • Evaluation of psychological needs of OFP patients and identify best practise in management

Relationship of Parkinson’s and orofacial pain

  • Epidemiology
 

Trigeminal nerve injuries

  • Prevention and management optimization
  • Psychological effects of iatrogenesis

Increasing patients awareness

  • Media activity in the BBC and Tribune
  • LA related nerve injuries
  • BDJ publication (second under way).
  • The dentist article (link?)
  • National survey of dentists’ experience of these nerve injuries.
  • Prospective study evaluating novel LA practise to minimise these injuries