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Areas of research interest

 

Acute post surgical pain model (basis of clinical analgesic trials)

Influence of genetics, psychometrics on pain (38 genes identified up regulated or down regulated in association with trigeminal pain)
Pain pathways fMRI
 
Biomarker of ongoing pain in man (proof of concept studies to follow with Perfalgen and Diclofenac)
 
Evaluation of the placebo effect
 
Immunohistochemical analysis peripheral pain receptors
 
 

Dental pulpal pain (unravelling the modality of dental pain and Dental Sensitivity)

 

Influence of genetics, psychometrics
Pain pathways fMRI insert video of MRI imaging in pain research
Immunohistochemical analysis peripheral receptors /effects of blocking agents
Evaluation of neurophysical and biological pathways
Cell culture of neural stem cells form dental pulp
Characterisation of neural cell physiology derived form human pulp
Evaluate novel methods of obliteration/obstruction of dentinal tubules
 

Chronic orofacial pain 

Conditions include headaches [migraine, tension, cluster, trigeminal autonomic syndromes, giant cell arteritis] neuralgias [trigeminal neuralgia –typical and atypical, post surgical neuropathy, PHN] and neuropathic pain [persistent idiopathic intra oral and extra oral pain, trigeminal neuropathy, Temporomandibular pain, burning mouth syndrome].
 
Phenotyping of patients attending OFP /neurology clinics 
(pain history / QST / LA blocks / Specific adjuvants)
Influence of genetics, psychometrics –pain questionnaires
Pain pathways fMRI
Immunohistochemical analysis peripheral receptors /effects of blocking agents
Evaluation of neurophysical and biological pathways
Evaluation of psychological needs of OFP patients and identify best practise in management
 
 
Relationship of Parkinson’s and orofacial pain
Epidemiology
 
 

Trigeminal nerve injuries

Prevention and management optimization
Psychological effects of iatrogenesis